19 最长寿啮齿动物

世界上最长寿的啮齿动物种类

Published

October 15, 2025

1. 裸鼹鼠（naked mole rat，Heterocephalus glaber）的寿命

读到一篇关于探讨裸鼹鼠的cGAS和抗衰老/anti-aging的研究论文(1)和对应的评论(2)。

研究论文(1)提到：

The naked mole-rat (Heterocephalus glaber) is an extraordinarily long-lived rodent with a maximum life span of ∼37 years.

对应的评论(2)提到：

The naked mole rat (Heterocephalus glaber) is the longest-lived rodent, with a maximum life span of nearly 40 years.

对该推文的笔者来说，算一个知识点，所以贴出来。

2. QuPath for fun

纯粹为了好玩，我们通过个性化groovy脚本在QuPath中标注裸鼹鼠的寿命特点。

批注大概从第8秒开始。

// QuPath v0.6.0

import qupath.lib.objects.PathObjects
import qupath.lib.roi.ROIs

// Set image type
setImageType('OTHER')

// Remove all existed objects
selectAllObjects()
removeAllObjects()

// Sleep for 30 seconds
Thread.sleep(30000)

// Draw a line (1st)
def line_x1 = 592; line_x2 = 724
def line_y1 = 835; line_y2 = 457
def plane = getCurrentViewer().getImagePlane()
def line1_roi = ROIs.createLineROI(line_x1, line_y1, line_x2, line_y2, plane)
def line1_anno = PathObjects.createAnnotationObject(line1_roi)
addObject(line1_anno)

// Sleep for 2 seconds
Thread.sleep(2000)

// Draw another line (2nd)
def line_x3 = line_x2; line_x4 = 2500
def line_y3 = line_y2; line_y4 = line_y2
def line2_roi = ROIs.createLineROI(line_x3, line_y3, line_x4, line_y4, plane)
def line2_anno = PathObjects.createAnnotationObject(line2_roi)
addObject(line2_anno)

// Sleep for 2 seconds
Thread.sleep(2000)

// Set a name to the 2nd line
def text = "I (naked mole rat/裸鼹鼠) am the longest-lived rodent, with a maximum life span of nearly 40 years :)"
def text_annotation = text
def text_annotation_obj = PathObjects.createAnnotationObject(line2_roi)
text_annotation_obj.setName(text_annotation)
addObject(text_annotation_obj)

// Sleep for 2 seconds
Thread.sleep(2000)

// Select all objects
selectAllObjects()

println("Done!")

给我买杯茶🍵

References

Y. Chen, Z. Chen, H. Wang, Z. Cui, K.-L. Li, Z. Song, L. Chen, X. Sun, X. Xu, Y. Zhang, L. Tan, J. Yuan, R. Tan, M.-H. Luo, F.-L. Sun, H. Liu, Y. Jiang, Z. Mao, A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging. Science 390 (2025).

J. C. Martinez, A. Seluanov, V. Gorbunova, Longevity steps on the cGAS. Science 390, 126–127 (2025).